Clinical Approach to Isolated Splenomegaly

Patients with splenomegaly may come to medical attention for a variety of reasons. However, patients with no obvious explanation for an enlarged spleen present a difficult diagnostic problem. A detailed history taking, appropriate clinical examination and relevant investigations is tool for a diagnosis of splenomegaly. Appropriate investigations in most patients with undiagnosed splenomegaly will yield a diagnosis. Patients with undiagnosed splenomegaly, who are otherwise well and who have no evidence of systemic diseases, particularly if the spleen is minimally enlarged, may be followed with careful and regular observation.